紫斑牡丹籽饼粕低聚芪类成分研究

刘普, 牛亚琪, 邓瑞雪, 卢宗元, 刘欣, 尹卫平*

中国药学杂志 ›› 2014, Vol. 49 ›› Issue (12) : 1018-1021.

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中国药学杂志 ›› 2014, Vol. 49 ›› Issue (12) : 1018-1021. DOI: 10.11669/cpj.2014.12.003
论 著

紫斑牡丹籽饼粕低聚芪类成分研究

  • 刘普, 牛亚琪, 邓瑞雪, 卢宗元, 刘欣, 尹卫平*
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Oligostilbenes Study from Seed Cakes of Paeonia rockii

  • LIU Pu, NIU Ya-qi, DENG Rui-xue, LU Zong-yuan, LIU Xin, YIN Wei-ping*
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摘要

目的 研究紫斑牡丹籽饼粕的化学成分。方法 采用硅胶柱色谱、凝胶柱色谱及制备高效液相色谱等多种色谱分离方法对紫斑牡丹籽饼粕丙酮提取物进行分离, 根据波谱数据分析鉴定化合物结构。结果 从紫斑牡丹籽饼粕的丙酮提取物中分离得到10个低聚芪类化合物, 分别为gnetin H(1), suffruticosol A(2), suffruticosol B(3), suffruticosol C(4), cis-ε-viniferin(5), trans-ε-viniferin(6), pauciflorol E(7), (+)-ampelopsin B(8), hopeafuran(9)和vitisinol C(10)。结论 所有化合物均为首次从油用紫斑牡丹籽饼粕中分离得到, 化合物7~10为首次从芍药科中分离得到。

Abstract

OBJECTIVE To study the chemical constituents of the seed cakes of Paeonia rockii. METHODS Chemical constituents were isolated by Sephadex LH-20, preparative HPLC, and silica gel column chromatography. The structures were elucidated on the basis of spectral data analysis. RESULTS Ten oligostilbenes compounds, gnetin H(1), suffruticosol A(2), suffruticosol B(3), suffruticosol C(4), cis-ε-Viniferin(5), trans-ε-viniferin(6), pauciflorol E(7), (+)-ampelopsin B(8), hopeafuran(9) and vitisinol C(10) were isolated from the seed cakes of Paeonia rockii. CONCLUSION All the compounds are isolated from the plant for the first time. Compounds 7-10 are isolated from the family of Paeoniaceae for the first time.

关键词

紫斑牡丹 / 籽饼粕 / 芪类化合物 / pauciflorolE / (+)-ampelopsinB / hopeafuran / vitisinolC

Key words

Paeonia rockii / seed cake / oligostilbene / pauciflorol E / (+)-ampelopsin B / hopeafuran / vitisinol C

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刘普, 牛亚琪, 邓瑞雪, 卢宗元, 刘欣, 尹卫平*. 紫斑牡丹籽饼粕低聚芪类成分研究[J]. 中国药学杂志, 2014, 49(12): 1018-1021 https://doi.org/10.11669/cpj.2014.12.003
LIU Pu, NIU Ya-qi, DENG Rui-xue, LU Zong-yuan, LIU Xin, YIN Wei-ping*. Oligostilbenes Study from Seed Cakes of Paeonia rockii[J]. Chinese Pharmaceutical Journal, 2014, 49(12): 1018-1021 https://doi.org/10.11669/cpj.2014.12.003
中图分类号: R284   

参考文献

[1] QI J C, ZHOU H M, MA J Q, et al. Analysis of the chemical constituents in Peony seed oil by GC-MS. Cereals Oils (粮食与油脂), 2005, 19(11):22-23.[2] SATYAJIT D S, PENSIRI W, LAURENCE D, et al. Identification and ecdysteroid antagonist activity of three resveratrol trimers(Suffruticosols A, B and C) from Paeonia suffruticosa. Tetrahedron, 1999, 55(2):513-524[3] HE C N, PENG Y, XU L J, et al.Three new oligostilbenes from the seeds of Paeonia suffruticosa. Chem Pharm Bull, 2010, 58(6):843-847.[4] KIM H J, CHANG E J, SONG J B, et al. Cytotoxic and an Umutagenic stilbenes from Seeds of Paeonia lactiflora. Arch Pharm Res, 2002, 25(3):293-299.[5] YUK H J, RYU H W, JEONG S H, et al. Profiling of neuraminidase inhibitory polyphenols from the seeds of Paeonia lactiflora. Food Chem Toxicol, 2013, 55:144-149.[6] LIU P, LI L, DENG R X, et al. Monoterpene glucosides in seed cakes of Paeonia ostii. Chin Pharm J(中国药学杂志), 2013, 48(17):1445-1448.[7] ITO T, TANAKA T, IINUMA M, et al. Three new resveratrol oligomers from the stem bark of Vatica pauciflora . J Nat Prod, 2004, 67(6):932-937.[8] YOSHITERU O, YUJI U, HIROSHI H, et al. Ampelopsins A, B and C, new oligostilbenes of ampelopsis brevipedunculata VAR hancei. Tetrahedron, 1990, 46(15):5121-5126.[9] TANAKA T, ITO T, IDO Y, et al. Hopeafuran and a C-glucosyl resveratrol isolated from stem wood of Hopea utilis. Chem Pharm Bull, 2001, 49(6):785-787. CHIOU W F, SHEN C C, CHEN C C, et al. Oligostilbenes from the roots of Vitis thunbergii. Planta Med, 2009, 75(8):856-859.

基金

河南科技大学自然科学领域创新能力培育基金资助项目(2012ZCX005);河南科技大学研究生创新基金(CXJJ-Z024)的资助
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